Caudal Granular Insular Cortex and the Maintenance of Allodynic behavior in the Rat
نویسندگان
چکیده
........................................................................................................4 Introduction.....................................................................................................5 Methods.........................................................................................................7 Somatosensory Evoked Potential Mapping...............................................8 Insular Excitotoxic Lesions.................................................................9 Chronic Constriction Injury................................................................9 Behavioral Measures – Von Frey Test, Calibrated Toe Pinch........................10 Spinal Laminar Multi-Unit Recording...................................................11 Analysis and Groups..........................................................................................12 Results..........................................................................................................14 Functional Mapping of CGIC............................................................14 Functional Lesion Verification............................................................14 Behavioral Effect of CGIC Lesion Before and After CCI...........................14 Spinal Laminar Multi-Unit Responses to CGIC Inactivation........................16 Discussion.....................................................................................................18 Two-Phase Model of Allodynia..........................................................19 Running Head: CAUDAL INSULA AND ALLODYNIA 3 Chronological Analysis of Cortically and Sciatic-Evoked Spinal MUA...........21 Proposed Mechanism of Maintenance of Allodynia...................................23 References.....................................................................................................26 Figures.........................................................................................................29 Running Head: CAUDAL INSULA AND ALLODYNIA 4
منابع مشابه
Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe symptom of chronic pain often produced by damage to peripheral nerves. Allodynia affects millions of people and remains highly resistant to classic analgesics and therapies. Neural mechanisms for the development and maintenance of allodynia have been investigated in the spinal cord, brainstem, thalamus...
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